Association of Cachexia and Gut Microbiome in Dialysis Patients : Investigation of the Interactions With Uremic Toxins and Inflammation.

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Cachexia is common in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Cachexia is a complex syndrome, in which inflammation and retention of uremic toxins are two main contributing factors. In this context, the role of the gut microbiome in CKD cachexia and the potential benefit of increasing the dialysis dose have been poorly explored. Here the investigators propose to study the links between cachexia and the gut microbiome, in association with inflammation and uremic toxins, in dialysis. The specific objectives are the followings: 1. Set up a prospective cohort of deeply characterized kidney failure patients treated with hemodialysis (in-center, self-care dialysis in a satellite unit and at home) and peritoneal dialysis, including evaluation of cachexia, body composition, collection of feces and blood to characterize the gut microbiota, measure serum levels of uremic toxins and inflammatory markers, with a longitudinal follow-up. 2. To compare cachectic versus non-cachectic dialysis patients in terms of gut microbiota, inflammatory markers, level of uremic toxins, muscle transcriptome, dialysis dose and modality. In a subgroup analysis, the investigators plan to compare the different techniques of dialysis (in-center vs home-hemodialysis vs peritoneal dialysis).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥ 18 years

• Diagnosis of kidney failure (stage V)

• Maintenance dialysis for at least 3 months

• Understanding of the trial procedures and ability to adhere to the trial protocol

Locations
Other Locations
Belgium
Cliniques universitaires Saint-Luc
RECRUITING
Brussels
UCLouvain
NOT_YET_RECRUITING
Brussels
Contact Information
Primary
Laure Bindels, PhD
laure.bindels@uclouvain.be
+32(2)7647337
Backup
Eric Goffin, MD
eric.goffin@saintluc.uclouvain.be
+32(2)7641855
Time Frame
Start Date: 2025-02-04
Estimated Completion Date: 2030-12
Participants
Target number of participants: 157
Treatments
Dialysis patients
Collection of clinical data and biological samples
Related Therapeutic Areas
Sponsors
Collaborators: Fonds National de la Recherche Scientifique, FRC- Fonds de la Recherche Clinique, SFNDT - Société Francophone de Néphrologie, Dialyse et Transplantation
Leads: Université Catholique de Louvain

This content was sourced from clinicaltrials.gov